3D Cell Culture at Scale for Next-Generation Drug Discovery

Syntopia combines advanced 3D cell culture, organoids, and innovative microfluidics to help to biotech and pharmaceutical industries generate high-quality biological data at scale - accelerating research and reducing clinical failure rates

Mission
The Challenge

In drug discovery, over 90% of drug candidates fail in clinical trials. Traditional models - 2D cell cultures and animal testing - poorly predict human biology, driving huge costs and delays for biotech and pharma.

Our Solution

At Syntopia, we aim to transform how drugs are developed by making advanced, human-relevant in vitro models scalable, accessible, and data-driven.
We build a platform that generate the high-quality datasets needed to power AI, improve predictivity, and accelerate the transition toward New Approach Methodologies.

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3D cell culture & organoids
Scaffold-based tissue models with long-term viability and functional assays

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Innovative microfluidics
Pump-free, open format, fully compatible with robotics - enabling high-throughput experiments and large-scale data generation without specialized instruments

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Multi-modal readouts
Immunofluorescence imaging, secretome chemical analysis, and RNA sequencing after treatment - delivering a comprehensive view of cell responses

Our Impact

We enable a new generation of drug discovery

Discover our applications
Applications & Modular Design

Our solution is modular - we can adapt the device design and assay configuration to meet specific application needs.
Current focus on three applications:

cells
1.
3D oncology & immuno-oncology
  • Patient-derived tumoroids / organoids with immune cell co-culture

  • Enables functional studies: migration, cytotoxicity, CAR-T/CAR-NK screening

2.
Hepatotoxicity (DILI)
  • Primary Human Hepatocyte model, viable > 21 days

  • Enables robust datasets for in silico toxicity prediction

3.
Neurotoxicity & Neuroinflammation
  • Brain microenvironment organoids integrating microglia

  • Supports personalized medicine and early-stage neurotoxicology

Discover our team
Credibility: Team & Partners
Adrien
Adrien Rennesson
CEO
Linkedin
Philippe
Philippe Nghe
CSO
Linkedin
They support us
Wilco
PSL Universite paris
PC-UP
ERC
pscc
Institut Carnot
ESPCI
BPI France
Agoranov
News
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October 2025

ELRIG Drug Discovery 2025

Join us us in the Breakthrough Zone in Liverpool (21–22 Oct 2025)

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September 2025

Joining Paris Saclay Cancer Cluster

French innovation hub that connects academia, hospitals, startups, and industry to accelerate cancer research and therapeutic development

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March 2025

Company creation & PC'Up integration

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September 2024

Winner of i-Lab
award

France’s national deep-tech innovation contest supporting early-stage startups with funding and visibility.

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September 2022

Winner of ERC PoC award

€150k EU funding to validate the commercial and societal potential of our research results.

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©️ Syntopia 2025